(S)-3,5-DHPG hydrochloride
Based on 1 Customer Validation
(S)-3,5-DHPG hydrochloride is a weak, but selective group I metabotropic glutamate receptors (mGluR) agonist with Ki values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively. (S)-3,5-DHPG hydrochloride exhibits anxiolytic activity in rats subjected to hypoxia.
For research use only. We do not sell to patients.
- CAS No.: 1822502-44-2
- Formula: C8H10ClNO4
- Molecular Weight:219.62
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
mGluR1a 0.9 μM (Ki) |
mGluR5a 3.9 μM (Ki) |
In Vitro
(S)-3,5-DHPG hydrochloride specifically displaces high-affinity quisqualate sites, the putative group I mGlu binding sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1822502-44-2
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Appearance Solid
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Molecular Weight 219.62
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Formula C8H10ClNO4
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SMILES
O=C(O)C(N)C1=CC(O)=CC(O)=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
References
[1]. V Mutel, et al. Characterization of [(3)H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections. J Neurochem. 2000 Dec;75(6):2590-601. [Content Brief]
[2]. Agnieszka Nadlewska, et al. Effect of (S)-3,5-DHPG on Learning, Exploratory Activity and Anxiety in Rats With Experimental Hypoxia. Pol J Pharmacol. Jan-Feb 2002;54(1):11-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-3,5-DHPG hydrochloride Related Classifications
HY-12598C Related Classifications
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