1841140-38-2
1841140-38-2
Chemical Structure
AIM4
- CAS No.: 1841140-38-2
- Formula:C25H23Br2N5O4
- Molecular Weight:617.29
InChIKey: BNJDRKWIHKVIGN-UHFFFAOYSA-N
SMILES: O=C(CN1C=C[N+](CC2=CC=CC3=CC4=CC=CC(C[N+]5=CN(CC(O)=O)C=C5)=C4N=C23)=C1)O.[Br-].[Br-]
Biological Activity: AIM4 is a TDP-43 aggregation inhibitor. AIM4 binds to the TDP-43 C-terminal amyloidogenic core and C-terminal fragments, antagonizing liquid-liquid phase separation, amyloid-like aggregation, and oligomer formation, while polarizing microglia toward an anti-inflammatory state. AIM4 can be used for research on amyotrophic lateral sclerosis[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AIM4 | 99.07% | AIM4 is a TDP-43 aggregation inhibitor. AIM4 binds to the TDP-43 C-terminal amyloidogenic core and C-terminal fragments, antagonizing liquid-liquid phase separation, amyloid-like aggregation, and oligomer formation, while polarizing microglia toward an anti-inflammatory state. AIM4 can be used for research on amyotrophic lateral sclerosis. | ||||||||||||||||||||
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References
- [1]. Prasad A, et al. An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models. Scientific reports. 2016 Dec 21;6:39490.
- [2]. Revi N, et al. Acridine Benzimidazolium Derivatives Induced Protective Microglia Polarization and TDP-43 Interaction─Potential Implications for Amyotrophic Lateral Sclerosis. ACS chemical neuroscience. 2025 Mar 19;16(6):1103-1116. [Content Brief]
- [3]. Girdhar A, et al. Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4. International journal of biological macromolecules. 2020 Mar 15;147:117-30.
- [4]. Nirwal S, et al. In vitro interaction of a C-terminal fragment of TDP-43 protein with human serum albumin modulates its aggregation. The Journal of Physical Chemistry B. 2022 Nov 3;126(45):9137-51.
- [5]. Moreno-Castro C, et al. Role of TCERG1 in the biogenesis of snRNPs.
