186492-53-5
Chemical Structure
14:0 EPC chloride
- CAS No.: 186492-53-5
- Formula:C38H77ClNO8P
- Molecular Weight:742.45
IUPAC Name: (1R,2S,5S)-3-((S)-2-(3-(1-((tert-butylsulfonyl)methyl)cyclohexyl)ureido)-3,3-dimethylbutanoyl)-N-((S)-1-((cyclopropyl-2,2,3,3-d4)amino)-1,2-dioxoheptan-3-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
InChIKey: KWNHEFTXCQPKSD-CZDORXJLSA-M
SMILES: C[N+](C)(C)CCOP(OC[C@@H](COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O)(OCC)=O.[Cl-]
Biological Activity: 14:0 EPC chlorid is a cationic lipid that efficiently mediates the transmembrane and intracellular delivery of nucleic acids and proteins. 14:0 EPC chlorid encapsulates nucleic acids through electrostatic interactions to form lipoplexes, thereby protecting nucleic acids from enzymatic degradation in vivo and effectively promoting their endocytosis and uptake by cells. 14:0 EPC chlorid can be used in research on cystic fibrosis, melanoma, and breast cancer[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
14:0 EPC chloride | 99.13% | 14:0 EPC chlorid is a cationic lipid that efficiently mediates the transmembrane and intracellular delivery of nucleic acids and proteins. 14:0 EPC chlorid encapsulates nucleic acids through electrostatic interactions to form lipoplexes, thereby protecting nucleic acids from enzymatic degradation in vivo and effectively promoting their endocytosis and uptake by cells. 14:0 EPC chlorid can be used in research on cystic fibrosis, melanoma, and breast cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Noone PG, et al. Safety and biological efficacy of a lipid–CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Molecular Therapy. 2000 Jan 1;1(1):105-14.
- [2]. Ferrari S, et al. Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium. Gene therapy. 2001 Sep;8(18):1380-6.
- [3]. Toyofuku K, et al. Non-Invasive Transdermal Delivery of Antisense Oligonucleotides with Biocompatible Ionic Liquids. ACS applied materials & interfaces. 2023 Jul 19;15(28):33299-33308.
- [4]. Zhang Y, et al. Lipids and Lipid Derivatives for RNA Delivery. Chemical reviews. 2021 Oct 27;121(20):12181-12277.
- [5]. Cui L, et al. Macromolecule-Loaded Hybrid Extracellular Vesicles via Ionic Lipid-Based Post-Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy. Journal of extracellular biology. 2026 Mar;5(3):e70125.
- [6]. Sarker MS, et al. Needle-free transdermal delivery of lipid-based ionic liquid-mediated laminarin-loaded solid-in-oil nanodispersion for enhanced antibody response. Chem Lett. 2026;55:upag127.
- [7]. Lonez C, et al. Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways. Nanomedicine : nanotechnology, biology, and medicine. 2014 May;10(4):775-82.
- [8]. Gorman CM, et al. Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC. Gene therapy. 1997 Sep;4(9):983-92. [Content Brief]
