197974-74-6
Chemical Structure
DMTAP
- CAS No.: 197974-74-6
- Formula:C34H68ClNO4
- Molecular Weight:590.36
IUPAC Name: N,N,N-trimethyl-2,3-bis(tetradecanoyloxy)propan-1-aminium chloride
InChIKey: WOSYUIOSAOFINL-UHFFFAOYSA-M
SMILES: CCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
Biological Activity: DMTAP is a cationic lipid. DMTAP inhibits PKC activity and reduces PKC-dependent cytokine secretion. DMTAP kills macrophages and monocyte-like cells, but not T lymphocytes. DMTAP induces CD80/CD86 in dendritic cells. DMTAP combined with DOPE (HY-112005)/DPPE inhibits nitric oxide, TNF-alpha, and Prostaglandin E2 (HY-101952). DMTAP can be used in research on inflammation and breast cancer[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DMTAP | 96.8% | DMTAP is a cationic lipid. DMTAP inhibits PKC activity and reduces PKC-dependent cytokine secretion. DMTAP kills macrophages and monocyte-like cells, but not T lymphocytes. DMTAP induces CD80/CD86 in dendritic cells. DMTAP combined with DOPE (HY-112005)/DPPE inhibits nitric oxide, TNF-alpha, and Prostaglandin E2 (HY-101952). DMTAP can be used in research on inflammation and breast cancer. | ||||||||||||||||||||
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References
- [1]. Filion MC, et al. Major limitations in the use of cationic liposomes for DNA delivery. International journal of pharmaceutics. 1998 Mar 20;162(1-2):159-70.
- [2]. Lonez C, et al. Cationic liposomal lipids: from gene carriers to cell signaling. Progress in lipid research. 2008 Sep;47(5):340-7.
- [3]. Filion MC, et al. Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells. Biochimica et biophysica acta. 1997 Oct 23;1329(2):345-56.
- [4]. Jones EM, et al. Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption. Biochemistry. 2012 Mar 27;51(12):2539-50.
- [5]. Filion MC, et al. Anti‐inflammatory activity of cationic lipids. British journal of pharmacology. 1997 Oct;122(3):551-7.
- [6]. Tanaka M, et al. Effects of charged lipids on the physicochemical and biological properties of lipid-styrene maleic acid copolymer discoidal particles. Biochimica et biophysica acta. Biomembranes. 2020 May 01;1862(5):183209.
