DMTAP
Based on 1 Customer Validation
DMTAP is a cationic lipid. DMTAP inhibits PKC activity and reduces PKC-dependent cytokine secretion. DMTAP kills macrophages and monocyte-like cells, but not T lymphocytes. DMTAP induces CD80/CD86 in dendritic cells. DMTAP combined with DOPE (HY-112005)/DPPE inhibits nitric oxide, TNF-alpha, and Prostaglandin E2 (HY-101952). DMTAP can be used in research on inflammation and breast cancer.
For research use only. We do not sell to patients.
- Purity : 96.8%
- CAS No.: 197974-74-6
- Formula: C34H68ClNO4
- Molecular Weight:590.36
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
![Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride](https://file.medchemexpress.com/product_pic/hy-w127644.gif)
Biological Activity
Description
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PKC |
CD80 |
CD86 |
TNF-alpha |
In Vitro
DMTAP alone is toxic to macrophages, and DOPE synergistically enhances DMTAP toxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 (female)[5]
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Dosage:60 mg/kg
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Administration:i.p.; once; 2 h before Carrageenan injection
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Result:Significantly reduced footpad volume at 3 h.
Maximum inhibition occurred at 48 h.
The reduction persisted for at least 72 h.
Chemical Information
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CAS No. 197974-74-6
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Appearance Solid
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Molecular Weight 590.36
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Formula C34H68ClNO4
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Color White to off-white
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SMILES
CCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
Ethanol : 20 mg/mL (33.88 mM; Need ultrasonic)
DMSO : 2 mg/mL (3.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.6939 mL | 8.4694 mL | 16.9388 mL | 42.3470 mL |
| Ethanol | 5 mM | 0.3388 mL | 1.6939 mL | 3.3878 mL | 8.4694 mL |
| 10 mM | 0.1694 mL | 0.8469 mL | 1.6939 mL | 4.2347 mL | |
| 15 mM | 0.1129 mL | 0.5646 mL | 1.1293 mL | 2.8231 mL | |
| 20 mM | 0.0847 mL | 0.4235 mL | 0.8469 mL | 2.1174 mL | |
| 25 mM | 0.0678 mL | 0.3388 mL | 0.6776 mL | 1.6939 mL | |
| 30 mM | 0.0565 mL | 0.2823 mL | 0.5646 mL | 1.4116 mL |
DMTAP Related Classifications
HY-112523A Related Classifications
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