198153-51-4
Chemical Structure
Peginterferon alfa-2a
Synonym(s): Ro 25-8310/000
- CAS No.: 198153-51-4
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Peginterferon alfa-2a]
Biological Activity: Peginterferon alfa-2a (Ro 25-8310/000) is a 40 kDa branched pegylated IFN alfa-2a with antiviral and immunomodulatory activities. Peginterferon alfa-2a binds to the Interferon Receptor on the surface of target cells, induces the formation of ISGF3, and promotes the expression of effector proteins such as interferon-stimulated genes (ISGs) and Mx proteins, thereby exerting sustained antiviral effects. Peginterferon alfa-2a is applicable to research on virus infections associated with chronic hepatitis C and chronic hepatitis B[1][2].
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Peginterferon alfa-2a | Peginterferon alfa-2a (Ro 25-8310/000) is a 40 kDa branched pegylated IFN alfa-2a with antiviral and immunomodulatory activities. Peginterferon alfa-2a binds to the Interferon Receptor on the surface of target cells, induces the formation of ISGF3, and promotes the expression of effector proteins such as interferon-stimulated genes (ISGs) and Mx proteins, thereby exerting sustained antiviral effects. Peginterferon alfa-2a is applicable to research on virus infections associated with chronic hepatitis C and chronic hepatitis B. | |||||||||||||||||||||
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References
- [1]. Matthews SJ, et al. Peginterferon alfa-2a: a review of approved and investigational uses. Clinical therapeutics. 2004 Jul;26(7):991-1025. [Content Brief]
- [2]. Rajender Reddy K, et al. Use of peginterferon alfa-2a (40 KD) (Pegasys) for the treatment of hepatitis C. Advanced drug delivery reviews. 2002 Jun 17;54(4):571-86. [Content Brief]
