20283-21-0
20283-21-0
Chemical Structure
1-Decanesulfonic acid
- CAS No.: 20283-21-0
- Formula:C10H22O3S
- Molecular Weight:222.34
IUPAC Name: decane-1-sulfonic acid
InChIKey: KVGOXGQSTGQXDD-UHFFFAOYSA-N
SMILES: O=S(=O)(O)CCCCCCCCCC
Biological Activity: 1-Decanesulfonic acid is an alkanesulfonate anionic surfactant that acts as a neutralizer of plasminogen activator inhibitor-1 (PAI-1). 1-Decanesulfonic acid binds to the hydrophobic region in the flexible linker domain of active PAI-1. 1-Decanesulfonic acid induces PAI-1 polymerization via a two-step neutralization mechanism[1][2].
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1-Decanesulfonic acid | 1-Decanesulfonic acid is an alkanesulfonate anionic surfactant that acts as a neutralizer of plasminogen activator inhibitor-1 (PAI-1). 1-Decanesulfonic acid binds to the hydrophobic region in the flexible linker domain of active PAI-1. 1-Decanesulfonic acid induces PAI-1 polymerization via a two-step neutralization mechanism. | |||||||||||||||||||||
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References
- [1]. Egelund R, et al. A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization. J Biol Chem. 2001 Apr 20;276(16):13077-86. [Content Brief]
- [2]. Bruzzoniti MC, et al. Determination of sulfonic acids and alkylsulfates by ion chromatography in water. Talanta. 2008 May 15;75(3):734-9. [Content Brief]
