212370-59-7
Chemical Structure
HS024
- CAS No.: 212370-59-7
- Formula:C58H79N19O10S2
- Molecular Weight:1266.50
InChIKey: PUOCNCOPVAOMDE-LQXMKOPKSA-N
SMILES: O=C([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC(CNC1=O)=O)C(N)=O)NC(C)=O)=O)CCCC)=O)CCCNC(N)=N)=O)CC2=CN=CN2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)N[C@H]1CC5=CNC6=CC=CC=C56
Biological Activity: HS024 is a peptide antagonist of melanocortin receptors with high affinity for the human melanocortin-4 receptor (MC4R). HS024 blocks α-MSH (HY-P0252)-induced cAMP accumulation and MC4 receptor signaling. HS024 induces dose-dependent feeding stimulation without affecting anxiety-related behavior or locomotor activity. HS024 can be used in research related to MC4 receptor-mediated diseases, such as eating disorders[1].
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HS024 | HS024 is a peptide antagonist of melanocortin receptors with high affinity for the human melanocortin-4 receptor (MC4R). HS024 blocks α-MSH (HY-P0252)-induced cAMP accumulation and MC4 receptor signaling. HS024 induces dose-dependent feeding stimulation without affecting anxiety-related behavior or locomotor activity. HS024 can be used in research related to MC4 receptor-mediated diseases, such as eating disorders. | |||||||||||||||||||||
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