2183473-45-0
Chemical Structure
BODIPY FL hydrazide hydrochloride
- CAS No.: 2183473-45-0
- Formula:C14H18BClF2N4O
- Molecular Weight:342.58
IUPAC Name: 3-(5,5-difluoro-7,9-dimethyl-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)propanehydrazide hydrochloride
InChIKey: YNMWMJPDWBHUBG-UHFFFAOYSA-N
SMILES: O=C(CCC1=CC=C2C=C3C(C)=CC(C)=[N]3[B+3]([F-])([N-]21)[F-])NN.Cl
Biological Activity: BODIPY FL hydrazide hydrochloride is a BODIPY-containing hydrazide fluorescent dye. BODIPY FL hydrazide hydrochloride is used to label carbonyl groups on oxidatively damaged proteins, 3-ketosteroids, and heparin/heparan sulfate carbohydrates. BODIPY FL hydrazide hydrochloride specifically binds to protein carbonyls, steroid keto groups, or reducing-end carbonyls of carbohydrates through derivatization or reductive amination via its hydrazide group to form stable conjugates; after the reaction is complete, the labeled molecules emit strong fluorescence (Ex/Em = 488-495/516-520 nm)[1][2][3].
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BODIPY FL hydrazide hydrochloride | BODIPY FL hydrazide hydrochloride is a BODIPY-containing hydrazide fluorescent dye. BODIPY FL hydrazide hydrochloride is used to label carbonyl groups on oxidatively damaged proteins, 3-ketosteroids, and heparin/heparan sulfate carbohydrates. BODIPY FL hydrazide hydrochloride specifically binds to protein carbonyls, steroid keto groups, or reducing-end carbonyls of carbohydrates through derivatization or reductive amination via its hydrazide group to form stable conjugates; after the reaction is complete, the labeled molecules emit strong fluorescence (Ex/Em = 488-495/516-520 nm). | |||||||||||||||||||||
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References
- [1]. Zardeneta G, et al. Iron-dependent generation of free radicals: plausible mechanisms in the progressive deterioration of the temporomandibular joint. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 2000 Mar;58(3):302-8; discussion 309.
- [2]. Katayama M, et al. Determination of progesterone and 17-hydroxyprogesterone by high performance liquid chromatography after pre-column derivatization with 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionohydra zide. The Analyst. 1998 Nov;123(11):2339-42. [Content Brief]
- [3]. Skidmore M, et al. Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations. Methods in molecular biology (Clifton, N.J.). 2009;534:157-69. [Content Brief]
