2223693-12-5
Chemical Structure
K‑Lock‑VC‑DUO‑5
Synonym(s): LDN1001
- CAS No.: 2223693-12-5
- Formula:C67H101F5N14O13
- Molecular Weight:1405.60
IUPAC Name: perfluorophenyl 1-(4-(((S)-1-(((S)-1-((4-((S)-3-azido-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)propyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoyl)piperidine-4-carboxylate
InChIKey: HYCONABCAPBJSP-OWMSIAKRSA-N
SMILES: O=C(N1CCC(CC1)C(OC2=C(C(F)=C(C(F)=C2F)F)F)=O)CCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C3)=CC=C3C[C@@H](CN=[N+]=[N-])NC([C@H](C)[C@H]([C@@]4([H])N(CCC4)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)=O)OC)=O)=O)=O)=O
Biological Activity: K-Lock-VC-DUO-5 is an antibody-drug conjugate (ADC) intermediate. K-Lock-VC-DUO-5 consists of a K-lock site-specific conjugation unit, a VC cleavable linker, and a cytotoxic payload DUO-5. K-Lock-VC-DUO-5 can be used for ADC synthesis in cancer-related research[1].
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K‑Lock‑VC‑DUO‑5 | K-Lock-VC-DUO-5 is an antibody-drug conjugate (ADC) intermediate. K-Lock-VC-DUO-5 consists of a K-lock site-specific conjugation unit, a VC cleavable linker, and a cytotoxic payload DUO-5. K-Lock-VC-DUO-5 can be used for ADC synthesis in cancer-related research. | |||||||||||||||||||||
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