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Cat. No.: HY-48887

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K‑Lock‑VC‑DUO‑5

Name: K‑Lock‑VC‑DUO‑5
Brand: MedChemExpress
SKU: HY-48887
Availability: PreOrder

(Synonyms: LDN1001)

K-Lock-VC-DUO-5 is an antibody-drug conjugate (ADC) intermediate. K-Lock-VC-DUO-5 consists of a K-lock site-specific conjugation unit, a VC cleavable linker, and a cytotoxic payload DUO-5. K-Lock-VC-DUO-5 can be used for ADC synthesis in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2223693-12-5
Formula: C₆₇H₁₀₁F₅N₁₄O₁₃
Molecular Weight:1405.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

K‑Lock‑VC‑DUO‑5 Chemical Structure

CAS No.: 2223693-12-5

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

Anti-cancer

An ADC (Antibody-Drug Conjugate) consists of three components: an antibody, a linker, and a cytotoxic payload. The antibody is responsible for targeting and recognizing tumor cells; the linker connects the antibody to the payload and undergoes cleavage intracellularly to release the toxin; and the payload exerts the effect of killing the tumor cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 2223693-12-5
Molecular Weight 1405.60
Formula C₆₇H₁₀₁F₅N₁₄O₁₃
SMILES

O=C(N1CCC(CC1)C(OC2=C(C(F)=C(C(F)=C2F)F)F)=O)CCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C3)=CC=C3C[C@@H](CN=[N+]=[N-])NC([C@H](C)[C@H]([C@@]4([H])N(CCC4)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)=O)OC)=O)=O)=O)=O
Synonyms

LDN1001
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gong J H, et al. An antibody-drug conjugate targeting CLDN18.2 and its preparation method and application. China, CN119792570A. 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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