232617-15-1
Chemical Structure
D-Ribose-L-cysteine
- CAS No.: 232617-15-1
- Formula:C8H15NO6S
- Molecular Weight:253.27
IUPAC Name: (4R)-2-((1R,2R,3R)-1,2,3,4-tetrahydroxybutyl)thiazolidine-4-carboxylic acid
InChIKey: AGZXTDUDXXPCMJ-HZYAIORGSA-N
SMILES: O=C(O)[C@H]1NC(SC1)[C@@H]([C@@H]([C@@H](CO)O)O)O
Biological Activity: D-Ribose-L-cysteine is an orally effective glutathione (GSH) precursor that crosses the blood-brain barrier. D-Ribose-L-cysteine exhibits potent antioxidant, anti-inflammatory, and neuro- and organ-protective activities. D-Ribose-L-cysteine exerts dual antioxidant and anti-inflammatory effects by promoting endogenous GSH synthesis to scavenge reactive oxygen species (ROS) and inhibiting NF-κB and the expression of its downstream pro-inflammatory factors (TNF-α, IL-6), thereby inhibiting apoptosis. D-Ribose-L-cysteine also reverses Scopolamine (HY-N0296)-induced memory impairment by inhibiting acetylcholinesterase (AChE) activity. D-Ribose-L-cysteine can be used in research on Alzheimer's disease, cardiometabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease[1][2][3][4][5][6][7][8][9][10].
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D-Ribose-L-cysteine | 99.79% | D-Ribose-L-cysteine is an orally effective glutathione (GSH) precursor that crosses the blood-brain barrier. D-Ribose-L-cysteine exhibits potent antioxidant, anti-inflammatory, and neuro- and organ-protective activities. D-Ribose-L-cysteine exerts dual antioxidant and anti-inflammatory effects by promoting endogenous GSH synthesis to scavenge reactive oxygen species (ROS) and inhibiting NF-κB and the expression of its downstream pro-inflammatory factors (TNF-α, IL-6), thereby inhibiting apoptosis. D-Ribose-L-cysteine also reverses Scopolamine (HY-N0296)-induced memory impairment by inhibiting acetylcholinesterase (AChE) activity. D-Ribose-L-cysteine can be used in research on Alzheimer's disease, cardiometabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease. | ||||||||||||||||||||
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References
- [1]. Isibor H, et al. D-ribose-L-cysteine reduces oxidative stress and inflammatory cytokines to mitigate liver damage, and memory decline induced by copper sulfate in mice. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2022 Sep;73:127001.
- [2]. Ojetola AA, et al. D-ribose-L-cysteine prevents oxidative stress and cardiometabolic syndrome in high fructose high fat diet fed rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct;142:112017.
- [3]. Ojetola AA, et al. Changes in antioxidants status, atherogenic index and cardiovascular variables after prolonged doses of D-ribose-L-cysteine in male Wistar rats. Heliyon. 2021 Feb;7(2):e06287.
- [4]. Akingbade GT, et al. D-Ribose-L-Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase-3 and GFAP Expressions Following Manganese-Induced Neurotoxicity. Neurotoxicity research. 2021 Dec;39(6):1846-1858.
- [5]. Inyang HO, et al. D-ribose-L-cysteine Attenuates manganese-induced Oxidative Stress, Neuromorphological Deficits, Bax/Bcl-2 Response and TNF-α/ERK Signalling in Rats. Neurochemical research. 2025 Jun 30;50(4):223.
- [6]. Akingbade GT, et al. D-Ribose-LCysteine attenuates manganese-induced cognitive and motor deficit, oxidative damage, and reactive microglia activation. Environmental Toxicology and Pharmacology. 2022 Jul 1;93:103872.
- [7]. Emokpae O, et al. D-ribose-L-cysteine enhances memory task, attenuates oxidative stress and acetyl-cholinesterase activity in scopolamine amnesic mice. Drug development research. 2020 Aug;81(5):620-627. [Content Brief]
- [8]. Emokpae O, et al. D-Ribose-L-cysteine attenuates lipopolysaccharide-induced memory deficits through inhibition of oxidative stress, release of proinflammatory cytokines, and nuclear factor-kappa B expression in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2020 May;393(5):909-925.
- [9]. Kader T, et al. Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. Atherosclerosis. 2014 Dec;237(2):725-33.
- [10]. Ojetola AA, et al. Dietary Supplementation with D-Ribose-L-Cysteine Prevents Hepatic Stress and Pro-Inflammatory Responses in Male Wistar Rats Fed a High-Fructose High-Fat Diet. Pathophysiology : the official journal of the International Society for Pathophysiology. 2022 Oct 31;29(4):631-639.
