2366983-10-8
Chemical Structure
MMV367
Synonym(s): GSK3772701; Anti-parasitic agent 3
- CAS No.: 2366983-10-8
- Formula:C21H22FN5O3
- Molecular Weight:411.43
IUPAC Name: ((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)(4-((R)-2-hydroxy-3-(2H-tetrazol-2-yl)propoxy)phenyl)methanone
InChIKey: RMWYAYFMEWWLSK-PKOBYXMFSA-N
SMILES: O=C(C1=CC=C(OC[C@H](O)CN2N=CN=N2)C=C1)N(CC3)C[C@H]3C4=CC=C(F)C=C4
Biological Activity: MMV367 is an orally effective inhibitor of Plasmodium falciparum acyl coenzyme A synthetase 10/11. MMV367 interferes with acyl coenzyme A synthetase function and parasite metabolism. MMV367 exhibits rapid parasiticidal activity and antimalarial effects against blood-stage Plasmodium falciparum, with no cross-resistance to existing antimalarial agents. MMV367 can be used in research related to Plasmodium falciparum malaria[1][2].
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MMV367 | MMV367 is an orally effective inhibitor of Plasmodium falciparum acyl coenzyme A synthetase 10/11. MMV367 interferes with acyl coenzyme A synthetase function and parasite metabolism. MMV367 exhibits rapid parasiticidal activity and antimalarial effects against blood-stage Plasmodium falciparum, with no cross-resistance to existing antimalarial agents. MMV367 can be used in research related to Plasmodium falciparum malaria. | |||||||||||||||||||||
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References
- [1]. Barber B E, et al. The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria[J]. Science Translational Medicine, 2026, 18(853): eaec1863.
- [2]. Kuemmerle A, et al. First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367. British journal of clinical pharmacology. 2025 Jun;91(6):1821-1833.
