2378640-67-4
2378640-67-4
Chemical Structure
PAN endonuclease-IN-1
- CAS No.: 2378640-67-4
- Formula:C14H8F3N5O4
- Molecular Weight:367.24
InChIKey: CTOQHZRTEVUPLN-UHFFFAOYSA-N
SMILES: O=C(C(NC(C1=C(C(F)(F)F)C=C(C2=NN=NN2)C=C1)=C3)=C(O)C3=O)O
Biological Activity: PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target[1].
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PAN endonuclease-IN-1 | PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target. | |||||||||||||||||||||
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