23911-26-4
Chemical Structure
DTPA anhydride
- CAS No.: 23911-26-4
- Formula:C14H19N3O8
- Molecular Weight:357.32
IUPAC Name: bis(2-(2,6-dioxomorpholino)ethyl)glycine
InChIKey: RAZLJUXJEOEYAM-UHFFFAOYSA-N
SMILES: O=C(CN(CCN1CC(OC(C1)=O)=O)CCN2CC(OC(C2)=O)=O)O
Biological Activity: DTPA anhydride is a bifunctional chelator precursor, and its anhydride group can react with primary amino groups in peptides, proteins, or polymers to form stable amide bonds, covalently linking the DTPA chelating scaffold to target molecules. DTPA anhydride reacts with the free amino termini of minigastrin and DGlu1-minigastrin to form DTPA-peptide conjugates without side-chain protection, and the resulting DTPA-conjugates can also bind radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs). RDCs possess the ability to specifically target biomolecules and can be applied in medical imaging[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
DTPA anhydride | 97.0% | DTPA anhydride is a bifunctional chelator precursor, and its anhydride group can react with primary amino groups in peptides, proteins, or polymers to form stable amide bonds, covalently linking the DTPA chelating scaffold to target molecules. DTPA anhydride reacts with the free amino termini of minigastrin and DGlu1-minigastrin to form DTPA-peptide conjugates without side-chain protection, and the resulting DTPA-conjugates can also bind radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs). RDCs possess the ability to specifically target biomolecules and can be applied in medical imaging. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Liu J, et al. Control of metal content in polystyrene microbeads prepared with metal complexes of DTPA derivatives. Chemistry of Materials. 2021 May 11;33(10):3802-13.
- [2]. Torchilin VP, et al. Chelating polymer modified monoclonal antibodies for radioimmunodiagnostics and radioimmunotherapy. Journal of controlled release. 1993 May 1;24(1-3):111-8.
- [3]. Okuda T, et al. Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration. Journal of controlled release : official journal of the Controlled Release Society. 2006 Aug 10;114(1):69-77.
- [4]. Béhé M, et al. Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives. European journal of nuclear medicine and molecular imaging. 2003 Aug;30(8):1140-6.
