DTPA anhydride
Based on 1 Customer Validation
DTPA anhydride is a bifunctional chelator precursor, and its anhydride group can react with primary amino groups in peptides, proteins, or polymers to form stable amide bonds, covalently linking the DTPA chelating scaffold to target molecules. DTPA anhydride reacts with the free amino termini of minigastrin and DGlu1-minigastrin to form DTPA-peptide conjugates without side-chain protection, and the resulting DTPA-conjugates can also bind radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs). RDCs possess the ability to specifically target biomolecules and can be applied in medical imaging.
For research use only. We do not sell to patients.
- Purity : 97.0%
- CAS No.: 23911-26-4
- Formula: C14H19N3O8
- Molecular Weight:357.32
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
RDC Bifunctional Chelator |
In Vitro
DTPA anhydride (112 µmo; 2 hours) couples to the N-terminal amino group of DGlu1-minigastrin and Leu1-minigastrin in a cell-free reaction to generate DTPA-DGlu1-minigastrin and DTPA-Leu1-minigastrin[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 23911-26-4
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Appearance Solid
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Molecular Weight 357.32
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Formula C14H19N3O8
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Color Off-white to light brown
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SMILES
O=C(CN(CCN1CC(OC(C1)=O)=O)CCN2CC(OC(C2)=O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 6.67 mg/mL (18.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7986 mL | 13.9931 mL | 27.9861 mL | 69.9653 mL |
| 5 mM | 0.5597 mL | 2.7986 mL | 5.5972 mL | 13.9931 mL | |
| 10 mM | 0.2799 mL | 1.3993 mL | 2.7986 mL | 6.9965 mL | |
| 15 mM | 0.1866 mL | 0.9329 mL | 1.8657 mL | 4.6644 mL |
DTPA anhydride Related Classifications
HY-W011118 Related Classifications
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