23950-58-5
Chemical Structure
Propyzamide
Synonym(s): Kerb; RH 315
- CAS No.: 23950-58-5
- Formula:C12H11Cl2NO
- Molecular Weight:256.13
IUPAC Name: 3,5-dichloro-N-(2-methylbut-3-yn-2-yl)benzamide
InChIKey: PHNUZKMIPFFYSO-UHFFFAOYSA-N
SMILES: O=C(NC(C)(C)C#C)C1=CC(Cl)=CC(Cl)=C1
Biological Activity: Propyzamide (Kerb) is an orally active inhibitor of β-tubulin and AHR signaling pathways. Propyzamide binds β-tubulin at the intradimer interface, disrupting microtubule assembly, leading to mitotic arrest and multipolar spindle formation. Propyzamide enhances C/EBPβ and NF-κB signaling, promoting colitogenic helper T cell differentiation and interleukin-17/interferon gamma-expressing colonic T cells. Propyzamide can be used in research on colitis, inflammatory bowel disease, and liver cancer[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Propyzamide | 99.77% | Propyzamide (Kerb) is an orally active inhibitor of β-tubulin and AHR signaling pathways. Propyzamide binds β-tubulin at the intradimer interface, disrupting microtubule assembly, leading to mitotic arrest and multipolar spindle formation. Propyzamide enhances C/EBPβ and NF-κB signaling, promoting colitogenic helper T cell differentiation and interleukin-17/interferon gamma-expressing colonic T cells. Propyzamide can be used in research on colitis, inflammatory bowel disease, and liver cancer. | ||||||||||||||||||||
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Propyzamide (Standard) | ≥98% | Propyzamide (Standard) (Kerb (Standard); RH 315 (Standard)) is the analytical standard of Propyzamide (HY-B1883). This product is intended for research and analytical applications. Propyzamide (Kerb) is an orally active inhibitor of β-tubulin and AHR signaling pathways. Propyzamide binds β-tubulin at the intradimer interface, disrupting microtubule assembly, leading to mitotic arrest and multipolar spindle formation. Propyzamide enhances C/EBPβ and NF-κB signaling, promoting colitogenic helper T cell differentiation and interleukin-17/interferon gamma-expressing colonic T cells. Propyzamide can be used in research on colitis, inflammatory bowel disease, and liver cancer. | ||||||||||||||||||||
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3,5-Dichloro-N-(2-methylbut-3-yn-2-yl)benzamide-d3 | 3,5-Dichloro-N-(2-methylbut-3-yn-2-yl)benzamide-d3 is the deuterium labeled 3,5-Dichloro-N-(2-methylbut-3-yn-2-yl)benzamide. 3,5-Dichloro-N-(2-methylbut-3-yn-2-yl)benzamide-d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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References
- [1]. Flemming A. ‘Prime and spike’induces mucosal immunity and reduces SARS-CoV-2 transmission: Covid-19. Nature Reviews Immunology. 2022 Dec;22(12):718-.
- [2]. Sanmarco LM, et al. Identification of environmental factors that promote intestinal inflammation. Nature. 2022 Nov;611(7937):801-809.
- [3]. Kiessig S, et al. Transcriptional insights into liver toxicity from mixture effects of pesticides and natural toxins: A case study of propyzamide and microcystins. Toxicology. 2026 Dec;527:154580.
- [4]. Wojtczak A. Differentiation Disorders of Chara vulgaris Spermatids following Treatment with Propyzamide. Cells. 2023 Apr 27;12(9):1268.
- [5]. Wojtczak A, et al. Effect of melatonin on propyzamide-induced stress tolerance in Vigna radiata (L.) R. Wilczek seedlings. BMC Plant Biology. 2026 Sep 3.
- [6]. Kaprocki K, et al. Comprehensive analysis of microtubule-inhibiting herbicides reveals shared subcellular phenotypes and distinct resistance profiles. Pest management science. 2026 Sep 02.
