2412273-76-6
Chemical Structure
PROTAC α-synuclein degrader 2
- CAS No.: 2412273-76-6
- Formula:C49H64N6O10S2
- Molecular Weight:961.20
IUPAC Name: (2S,4R)-1-((S)-2-(tert-butyl)-20-((2-(4-(methylamino)phenyl)benzo[d]thiazol-6-yl)oxy)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: RSKMHCDWHUBUGY-NLMYEZHISA-N
SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOC4=CC=C(N=C(C5=CC=C(C=C5)NC)S6)C6=C4)=O
Biological Activity: PROTAC α-synuclein degrader 2 is a potent α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 2 induces ubiquitination and proteasomal degradation of α-synuclein by bridging α-synuclein with the VHL E3 ubiquitin ligase. PROTAC α-synuclein degrader 2 can be used in the research of Parkinson's disease and Alzheimer's disease[1].
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PROTAC α-synuclein degrader 2 | PROTAC α-synuclein degrader 2 is a potent α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 2 induces ubiquitination and proteasomal degradation of α-synuclein by bridging α-synuclein with the VHL E3 ubiquitin ligase. PROTAC α-synuclein degrader 2 can be used in the research of Parkinson's disease and Alzheimer's disease. | |||||||||||||||||||||
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