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Cat. No.: HY-136000

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PROTAC α-synuclein degrader 2

PROTAC α-synuclein degrader 2 is a potent α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 2 induces ubiquitination and proteasomal degradation of α-synuclein by bridging α-synuclein with the VHL E3 ubiquitin ligase. PROTAC α-synuclein degrader 2 can be used in the research of Parkinson's disease and Alzheimer's disease.
(Pink: α-synuclein ligand (HY-W278021); Blue: VHL ligand (HY-112078); Black: linker (HY-134750)).

For research use only. We do not sell to patients.

CAS No.: 2412273-76-6
Formula: C₄₉H₆₄N₆O₁₀S₂
Molecular Weight:961.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC α-synuclein degrader 2 Chemical Structure

CAS No.: 2412273-76-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

PROTAC α-synuclein degrader 2 is a potent α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 2 induces ubiquitination and proteasomal degradation of α-synuclein by bridging α-synuclein with the VHL E3 ubiquitin ligase. PROTAC α-synuclein degrader 2 can be used in the research of Parkinson's disease and Alzheimer's disease^[1]. (Pink: α-synuclein ligand (HY-W278021); Blue: VHL ligand (HY-112078); Black: linker (HY-134750)).

IC₅₀ & Target

^[1]

α-synuclein

In Vitro

Aβ/Tau/α-Synuclein Aggregation

PROTAC α-synuclein degrader 2 (compound 4) (1 μM) potently induces degradation of α-synuclein in HEK293 TREX α-syn^A53T cells, with less than 35% of the protein remaining relative to DMSO control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2412273-76-6
Molecular Weight 961.20
Formula C₄₉H₆₄N₆O₁₀S₂
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOC4=CC=C(N=C(C5=CC=C(C=C5)NC)S6)C6=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kargbo RB. PROTAC Compounds Targeting α-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer's and Parkinson's Diseases. ACS Med Chem Lett. 2020 Apr 28;11(6):1086-1087.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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