2416857-24-2
2416857-24-2
Chemical Structure
Frunexian hydrochloride
Synonym(s): EP-7041 hydrochloride
- CAS No.: 2416857-24-2
- Formula:C19H27ClN4O4
- Molecular Weight:410.90
IUPAC Name: (2S,3R)-3-((2-aminopyridin-4-yl)methyl)-1-(((R)-1-cyclohexylethyl)carbamoyl)-4-oxoazetidine-2-carboxylic acid hydrochloride
InChIKey: DKVCWNHVUVKKRJ-WRVPCBEASA-N
SMILES: OC([C@@H](N(C1=O)C(N[C@@H](C2CCCCC2)C)=O)[C@H]1CC3=CC=NC(N)=C3)=O.Cl
Biological Activity: Frunexian hydrochloride (EP-7041 hydrochloride) is a potent and selective FXIa inhibitor. Frunexian hydrochloride produces anticoagulant effects and rapidly restores normal coagulation function. Frunexian hydrochloride can be used in thrombosis research[1][2][3][4].
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Frunexian hydrochloride | Frunexian hydrochloride (EP-7041 hydrochloride) is a potent and selective FXIa inhibitor. Frunexian hydrochloride produces anticoagulant effects and rapidly restores normal coagulation function. Frunexian hydrochloride can be used in thrombosis research. | |||||||||||||||||||||
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References
- [1]. Vedovati MC, et al. A new strategy for anticoagulation: The factor XI inhibitors. European journal of internal medicine. 2023 Oct;116:8-15.
- [2]. Prakash S, et al. Factor XI/XIa inhibitors for the prevention and treatment of venous and arterial thromboembolism: A narrative review. Vascular medicine (London, England). 2024 Feb;29(1):85-92. [Content Brief]
- [3]. Prisco D, et al. Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke. Internal and emergency medicine. 2024 Oct;19(7):1807-1819.
- [4]. Zhang JY, et al. Pharmacokinetics, pharmacodynamics, and safety of frunexian in healthy Chinese volunteer adults: A randomized dose-escalation phase I study. Clinical and translational science. 2024 Apr;17(4):e13787. [Content Brief]
