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Cat. No.: HY-156613A

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Frunexian hydrochloride

Name: Frunexian hydrochloride
Brand: MedChemExpress
SKU: HY-156613A
Availability: PreOrder

(Synonyms: EP-7041 hydrochloride)

Frunexian hydrochloride (EP-7041 hydrochloride) is a potent and selective FXIa inhibitor. Frunexian hydrochloride produces anticoagulant effects and rapidly restores normal coagulation function. Frunexian hydrochloride can be used in thrombosis research.

For research use only. We do not sell to patients.

CAS No.: 2416857-24-2
Formula: C₁₉H₂₇ClN₄O₄
Molecular Weight:410.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Frunexian hydrochloride Chemical Structure

CAS No.: 2416857-24-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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References
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Biological Activity

Description

In Vitro

Local Vascular Regulation

Frunexian both blocks the key role of FXIa in contact activation pathway thrombin generation and simultaneously inhibits the significant enhancing effect of FXIa in tissue factor-initiated thrombin generation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Local Vascular Regulation

Frunexian (intravenous injection) rapidly produces an anticoagulant effect and rapidly restores normal coagulation function^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2416857-24-2
Molecular Weight 410.90
Formula C₁₉H₂₇ClN₄O₄
SMILES

OC([C@@H](N(C1=O)C(N[C@@H](C2CCCCC2)C)=O)[C@H]1CC3=CC=NC(N)=C3)=O.Cl
Synonyms

EP-7041 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vedovati MC, et al. A new strategy for anticoagulation: The factor XI inhibitors. European journal of internal medicine. 2023 Oct;116:8-15.

[2]. Prakash S, et al. Factor XI/XIa inhibitors for the prevention and treatment of venous and arterial thromboembolism: A narrative review. Vascular medicine (London, England). 2024 Feb;29(1):85-92. [Content Brief]

[3]. Prisco D, et al. Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke. Internal and emergency medicine. 2024 Oct;19(7):1807-1819.

[4]. Zhang JY, et al. Pharmacokinetics, pharmacodynamics, and safety of frunexian in healthy Chinese volunteer adults: A randomized dose-escalation phase I study. Clinical and translational science. 2024 Apr;17(4):e13787. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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