2428737-31-7
2428737-31-7
Chemical Structure
TM-04-176-01
Synonym(s): PI5P4Kα-IN-1
- CAS No.: 2428737-31-7
- Formula:C20H17N3O2S
- Molecular Weight:363.43
IUPAC Name: N-(4-(5-(1H-indol-4-yl)pyridin-3-yl)phenyl)methanesulfonamide
InChIKey: KKMZWHRTQLNOCF-UHFFFAOYSA-N
SMILES: O=S(NC1=CC=C(C2=CC(C3=C4C=CNC4=CC=C3)=CN=C2)C=C1)(C)=O
Biological Activity: TM-04-176-01 (PI5P4Kα-IN-1) is a selective PIP4K2C inhibitor (Kd 3.4 nM) and PI5P4K inhibitor (IC50: 1.96 and 9.4 μM for PI5P4Kα and PI5P4Kβ, respectively). TM-04-176-01 inhibits SARS-CoV-2 replication with low cytotoxicity. TM-04-176-01 can be used for research on SARS-CoV-2 infection[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TM-04-176-01 | 99.60% | TM-04-176-01 (PI5P4Kα-IN-1) is a selective PIP4K2C inhibitor (Kd 3.4 nM) and PI5P4K inhibitor (IC50: 1.96 and 9.4 μM for PI5P4Kα and PI5P4Kβ, respectively). TM-04-176-01 inhibits SARS-CoV-2 replication with low cytotoxicity. TM-04-176-01 can be used for research on SARS-CoV-2 infection. | ||||||||||||||||||||
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References
- [1]. Manz TD, et al. Discovery and Structure-Activity Relationship Study of ()-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Journal of medicinal chemistry. 2020 May 14;63(9):4880-4895. [Content Brief]
- [2]. Karim M, et al. PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2. Nature communications. 2025 Jul 10;16(1):6397.
