244095-36-1
Chemical Structure
TFLLRN-NH2
- CAS No.: 244095-36-1
- Formula:C35H59N11O8
- Molecular Weight:761.91
InChIKey: RNTAAFDNJNFOMJ-GSAYKZDLSA-N
SMILES: NC(C[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O
Biological Activity: TFLLRN-NH2 is a PAR-1 peptide-selective agonist. TFLLRN-NH2 induces AMPK phosphorylation and attenuates LPS-induced osteoclastogenesis, NFATc1 expression, NF-κB activation, and IκBα degradation. TFLLRN-NH2 stimulates MAPK phosphorylation in hepatocellular carcinoma cells. TFLLRN-NH2 induces concentration-dependent contraction of isolated human renal artery rings, stimulates IL-6 release from human T cells, and also evokes intracellular Ca2+ mobilization in primary human renal tubular epithelial cells. TFLLRN-NH2 can be used in research related to hepatocellular carcinoma and acute lung injury[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TFLLRN-NH2 | 99.71% | TFLLRN-NH2 is a PAR-1 peptide-selective agonist. TFLLRN-NH2 induces AMPK phosphorylation and attenuates LPS-induced osteoclastogenesis, NFATc1 expression, NF-κB activation, and IκBα degradation. TFLLRN-NH2 stimulates MAPK phosphorylation in hepatocellular carcinoma cells. TFLLRN-NH2 induces concentration-dependent contraction of isolated human renal artery rings, stimulates IL-6 release from human T cells, and also evokes intracellular Ca2+ mobilization in primary human renal tubular epithelial cells. TFLLRN-NH2 can be used in research related to hepatocellular carcinoma and acute lung injury. | ||||||||||||||||||||
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References
- [1]. Kanno Y, et al. uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca(2+)/CaMKK/AMPK Axis. International journal of biological sciences. 2016;12(1):63-71.
- [2]. Kaufmann R, et al. Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation. Oncology reports. 2009 May;21(5):1261-7.
- [3]. Li T, et al. Induction of IL‐6 release from human T cells by PAR‐1 and PAR‐2 agonists. Immunology and cell biology. 2006 Oct;84(5):461-6.
- [4]. Tognetto M, et al. Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro. British journal of pharmacology. 2003 May;139(1):21-7.
- [5]. Iyer A, et al. PAR2 Activation on Human Kidney Tubular Epithelial Cells Induces Tissue Factor Synthesis, That Enhances Blood Clotting. Frontiers in physiology. 2021;12:615428.
