2445597-31-7
2445597-31-7
Chemical Structure
AB-836
- CAS No.: 2445597-31-7
- Formula:C20H15F3N4O2
- Molecular Weight:400.35
IUPAC Name: tert-butyl piperazine-1-carboxylate-3,3,5,5-d4
InChIKey: WKCMLORRPISTPL-SNVBAGLBSA-N
SMILES: FC1=C(C#N)C=C(NC(N(C)[C@H](C)C2=CNC(C3=C2C=C(F)C(F)=C3)=O)=O)C=C1
Biological Activity: AB-836 is an orally active HBV capsid inhibitor. AB-836 inhibits viral replication by interacting with HBV core protein. AB-836 can be used in research related to chronic hepatitis B[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AB-836 | 99.13% | AB-836 is an orally active HBV capsid inhibitor. AB-836 inhibits viral replication by interacting with HBV core protein. AB-836 can be used in research related to chronic hepatitis B. | ||||||||||||||||||||
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PSB-1434 | 98.05% | PSB-1434 is a selective monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.59 nM. PSB-1434 shows >6000-fold selective for MAO-B than MAO-A. | ||||||||||||||||||||
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PJ34 hydrochloride (Standard) | ≥98% | PJ34 (hydrochloride) (Standard) is the analytical standard of PJ34 (hydrochloride). This product is intended for research and analytical applications. PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively. | ||||||||||||||||||||
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TP0480066 | TP0480066 is a selective topoisomerase II inhibitor with IC50s of 1.10 and 62.89 nM for DNA gyrase and topo IV, respectively. TP0480066 shows good activity of againsting various bacterial species including drug-resistant strains. TP0480066 also exhibits potent inhibitory activity to N. gonorrhoeae, can be used in study of gonorrhea. | |||||||||||||||||||||
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Myosin modulator 1 | Myosin modulator 1 (Compound B141) is a modulator for myosin, that inhibits ATPase in rabbits psoas, porcine atria and in porcine ventricle, with IC25s of 0.42, 0.13 and 3.09 μM, respectively. Myosin modulator 1 regulates systolic cardiac performance in Sprague Dawley rats. | |||||||||||||||||||||
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Verosudil | 98.22% | Verosudil (AR-12286) is a ROCK inhibitor. Verosudil has equal inhibitory activity against ROCK1 and ROCK2 (Ki: 2 nM). Verosudil is less selective for PKA, PKCT, MRCKA, and CAM2A (Ki: 69 nM, 9322 nM, 28 nM, 5855 nM, respectively). Verosudil increases trabecular outflow capacity to reduce intraocular pressure. Verosudil is useful in the study of glaucoma and ocular hypertension. | ||||||||||||||||||||
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Verosudil hydrochloride | Verosudil (AR-12286) hydrochloride is the hydrochloride form of Verosudil (HY-16758). Verosudil hydrochloride is a ROCK inhibitor. Verosudil hydrochloride has equal inhibitory activity against ROCK1 and ROCK2 (Ki: 2 nM). Verosudil hydrochloride is less selective for PKA, PKCT, MRCKA, and CAM2A (Ki: 69 nM, 9322 nM, 28 nM, 5855 nM, respectively). Verosudil hydrochloride increases trabecular outflow capacity to reduce intraocular pressure. Verosudil hydrochloride is useful in the study of glaucoma and ocular hypertension. | |||||||||||||||||||||
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HBV-IN-48 | HBV-IN-48 is an HBV inhibitor. HBV-IN-48 has antiviral activity against HBV in HepDE19 cells, with an EC50 value of 0.005 μM. HBV-IN-48 can reduce serum HBV DNA levels in mouse models of HBV infection. |
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(+)-SJ733 | 99.79% | (+)-SJ733 is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4. | ||||||||||||||||||||
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SB-408124 (Standard) | ≥98% | SB-408124 (Standard) is the analytical standard of SB-408124. This product is intended for research and analytical applications. SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor. | ||||||||||||||||||||
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SB-408124 Hydrochloride (Standard) | ≥98% | SB-408124 (Hydrochloride) (Standard) is the analytical standard of SB-408124 (Hydrochloride). This product is intended for research and analytical applications. SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor. | ||||||||||||||||||||
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References
- [1]. Degasperi E, et al. Towards a Functional Cure for Hepatitis B Virus: A 2022 Update on New Antiviral Strategies. Viruses. 2022;14(11):2404. Published 2022 Oct 29. [Content Brief]
- [2]. Lam AM, et al. Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus. Antiviral Res. 2024;231:106010. [Content Brief]
