2477651-11-7
2477651-11-7
Chemical Structure
USP8-IN-2
- CAS No.: 2477651-11-7
- Formula:C19H20ClF3N4OS
- Molecular Weight:444.90
IUPAC Name: 1-(5-chloro-2-methoxyphenyl)-3-(1-(6-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)thiourea
InChIKey: XKLBIJSKEVHKCM-UHFFFAOYSA-N
SMILES: FC(F)(C1=NC(N2CCC(CC2)NC(NC3=CC(Cl)=CC=C3OC)=S)=CC=C1)F
Biological Activity: USP8-IN-2 (Compd U52) is a deubiquitinase USP8 inhibitor with an IC50 value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI50 value of 24.93 μM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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USP8-IN-2 | 99.91% | USP8-IN-2 (Compd U52) is a deubiquitinase USP8 inhibitor with an IC50 value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI50 value of 24.93 μM, respectively. | ||||||||||||||||||||
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SB-705498 (Standard) | ≥98% | SB-705498 (Standard) is the analytical standard of SB-705498 (HY-10633). This product is intended for research and analytical applications. SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. | ||||||||||||||||||||
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A 1070722 | 99.87% | A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain. A 1070722 decreases spontaneous locomotion. | ||||||||||||||||||||
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DO-264 | 99.96% | DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM. | ||||||||||||||||||||
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AKOS024836912 | AKOS024836912 is a EGFR-EGF interaction inhibitor. AKOS024836912 is applicable to research related to non-small cell lung cancer. | |||||||||||||||||||||
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ML267 free base | 98.45% | ML267 free base is a blood-brain barrier permeable Antibacterial agent and bacterial phosphopantetheinyl transferase (PPTase) inhibitor, with an IC50 of 0.29 μM against Bacillus subtilis Sfp-PPTase and an IC50 of 8.1 μM against bacterial AcpS-PPTase. ML267 free base attenuates bacterial secondary metabolism, activity, and the production of Sfp-PPTase-dependent metabolites. ML267 free base inhibits the growth of Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus. ML267 free base is applicable to research related to bacterial infections, including methicillin-resistant Staphylococcus aureus infections. | ||||||||||||||||||||
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RBP4 ligand-1 | RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4-TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively. | |||||||||||||||||||||
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WAY-354436 | ≥98.0% | WAY-354436 is an active molecule. | ||||||||||||||||||||
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USP8-IN-3 | 98.37% | USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively. | ||||||||||||||||||||
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AW01178 | AW01178 is a Class I HDAC inhibitor. AW01178 induces the upregulation of E-cadherin at both mRNA and protein levels and inhibits the EMT of breast cancer cells. | |||||||||||||||||||||
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LAG-3 biner 1 | 97.08% | LAG-3 biner 1 (compound 3) is a small molecule ligand (Kd=1.23 μM) for the immune checkpoint lymphocyte activation gene 3 (LAG-3). LAG-3 biner 1 can be used in the research of cancer diagnosis targeting LAG-3. | ||||||||||||||||||||
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