2495748-86-0
Chemical Structure
Coumarin-based kinetic stabilizer-2
- CAS No.: 2495748-86-0
- Formula:C27H30N4O4
- Molecular Weight:474.55
InChIKey: WFSFODPKYFDLDK-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=CC(C2=CN=CN2)=C1)OCCC3=C(C)C4=C(C=C(N(CC)CC)C=C4)OC3=O
Biological Activity: Coumarin-based kinetic stabilizer-2 is a 3-substituted coumarin-carbamate-distal substructure derivative and a kinetic stabilizer of amyloidogenic immunoglobulin light chain (FL LC) dimers. Coumarin-based kinetic stabilizer-2 stabilizes the native conformation of immunoglobulin light chains, reduces protein misfolding and proteolytic hydrolysis, with an EC50 value of 77.1 nM for the human target and an EC50 value of 27.9 nM for the WIL-FL T46L/F49Y variant. Coumarin-based kinetic stabilizer-2 can be used in research related to immunoglobulin light chain amyloidosis[1].
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Coumarin-based kinetic stabilizer-2 | Coumarin-based kinetic stabilizer-2 is a 3-substituted coumarin-carbamate-distal substructure derivative and a kinetic stabilizer of amyloidogenic immunoglobulin light chain (FL LC) dimers. Coumarin-based kinetic stabilizer-2 stabilizes the native conformation of immunoglobulin light chains, reduces protein misfolding and proteolytic hydrolysis, with an EC50 value of 77.1 nM for the human target and an EC50 value of 27.9 nM for the WIL-FL T46L/F49Y variant. Coumarin-based kinetic stabilizer-2 can be used in research related to immunoglobulin light chain amyloidosis. | |||||||||||||||||||||
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