2495749-21-6
2495749-21-6
Chemical Structure
Coumarin-based kinetic stabilizer-1
- CAS No.: 2495749-21-6
- Formula:C26H30N6O5
- Molecular Weight:506.55
InChIKey: PPPMGHIAXOKKFC-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(C)=C1CCN3C(NC4(CN(CC4)C(C5=CN=CN5)=O)C3=O)=O)C=CC(N(CC)CC)=C2
Biological Activity: Coumarin-based kinetic stabilizer-1 is an immunoglobulin light chain dimer stabilizer (human EC50 = 1880 nM) that stabilizes native LC dimers by binding to the VL-VL interface, reduces misfolding and proteolysis, and prevents aggregation of amyloidogenic light chains. Coumarin-based kinetic stabilizer-1 can be used in research on immunoglobulin light chain amyloidosis[1].
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Coumarin-based kinetic stabilizer-1 | Coumarin-based kinetic stabilizer-1 is an immunoglobulin light chain dimer stabilizer (human EC50 = 1880 nM) that stabilizes native LC dimers by binding to the VL-VL interface, reduces misfolding and proteolysis, and prevents aggregation of amyloidogenic light chains. Coumarin-based kinetic stabilizer-1 can be used in research on immunoglobulin light chain amyloidosis. | |||||||||||||||||||||
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