254103-71-4
Chemical Structure
p53 Bipartite NLS
- CAS No.: 254103-71-4
- Formula:C85H148N28O26
- Molecular Weight:1978.26
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: p53 Bipartite NLS is a bipartite nuclear localization signal derived from p53. When p53 Bipartite NLS is fused to the N-terminus of p65 and the single-component nuclear localization signal of p65 itself is mutated, it alters the nuclear import pathway of p65. p53 Bipartite NLS renders p65 resistant to TTP (HY-P60128)-mediated inhibition of NF-κB transcriptional activity and nuclear import[1].
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p53 Bipartite NLS | p53 Bipartite NLS is a bipartite nuclear localization signal derived from p53. When p53 Bipartite NLS is fused to the N-terminus of p65 and the single-component nuclear localization signal of p65 itself is mutated, it alters the nuclear import pathway of p65. p53 Bipartite NLS renders p65 resistant to TTP (HY-P60128)-mediated inhibition of NF-κB transcriptional activity and nuclear import. | |||||||||||||||||||||
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