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Cat. No.: HY-P11947

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p53 Bipartite NLS

p53 Bipartite NLS is a bipartite nuclear localization signal derived from p53. When p53 Bipartite NLS is fused to the N-terminus of p65 and the single-component nuclear localization signal of p65 itself is mutated, it alters the nuclear import pathway of p65. p53 Bipartite NLS renders p65 resistant to TTP (HY-P60128)-mediated inhibition of NF-κB transcriptional activity and nuclear import.

For research use only. We do not sell to patients.

CAS No.: 254103-71-4
Formula: C₈₅H₁₄₈N₂₈O₂₆
Molecular Weight:1978.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

p53 Bipartite NLS Chemical Structure

CAS No.: 254103-71-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All NF-κB Isoforms :

In Vitro

Innate Immunity

p53 Bipartite NLS confers partial resistance to TTP-mediated inhibition of p65-driven NF-κB-dependent luciferase activity in HEK 293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 254103-71-4
Molecular Weight 1978.26
Formula C₈₅H₁₄₈N₂₈O₂₆
SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Sequence

Lys-Arg-Ala-Leu-Pro-Asn-Asn-Thr-Ser-Ser-Ser-Pro-Gln-Pro-Lys-Lys-Lys-Pro
Sequence Shortening

KRALPNNTSSSPQPKKKP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schichl YM, et al. Tristetraprolin impairs NF-kappaB/p65 nuclear translocation. J Biol Chem. 2009 Oct 23;284(43):29571-81.
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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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