p53 Bipartite NLS TFA
Based on 1 Customer Validation
p53 Bipartite NLS TFA is a bipartite nuclear localization signal derived from p53. When p53 Bipartite NLS TFA is fused to the N-terminus of p65 and the single-component nuclear localization signal of p65 itself is mutated, it alters the nuclear import pathway of p65. p53 Bipartite NLS TFA renders p65 resistant to TTP (HY-P60128)-mediated inhibition of NF-κB transcriptional activity and nuclear import.
For research use only. We do not sell to patients.
- Formula: C85H148N28O26·xC2HF3O2
- Molecular Weight:1978.26 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 1978.26 (free base)
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Formula C85H148N28O26·xC2HF3O2
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SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N.O=C(O)C(F)(F)F.[x]
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Sequence
Lys-Arg-Ala-Leu-Pro-Asn-Asn-Thr-Ser-Ser-Ser-Pro-Gln-Pro-Lys-Lys-Lys-Pro
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Sequence Shortening
KRALPNNTSSSPQPKKKP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p53 Bipartite NLS TFA Related Classifications
HY-P11947A Related Classifications
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