260046-94-4
260046-94-4
Chemical Structure
Pim-1 kinase-IN-18
- CAS No.: 260046-94-4
- Formula:C19H15N3O2
- Molecular Weight:317.34
InChIKey: QQIDKHGRFGSXSN-YBEGLDIGSA-N
SMILES: COC1=CC=C(C2=NNC=C2/C=C3C(C=CC=C4)=C4NC/3=O)C=C1
Biological Activity: Pim-1 kinase-IN-18 is a Pim-1 kinase inhibitor with an IC50 of 5.77 µM. Pim-1 kinase-IN-18 inhibits Pim serine/threonine kinase activity by occupying the ATP binding site, its pyrazole ring forms dual polar interactions with residues in the catalytic region, and its oxindole binds to the hinge region. Pim-1 kinase-IN-18 can be used in cancer-related research[1].
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Pim-1 kinase-IN-18 | Pim-1 kinase-IN-18 is a Pim-1 kinase inhibitor with an IC50 of 5.77 µM. Pim-1 kinase-IN-18 inhibits Pim serine/threonine kinase activity by occupying the ATP binding site, its pyrazole ring forms dual polar interactions with residues in the catalytic region, and its oxindole binds to the hinge region. Pim-1 kinase-IN-18 can be used in cancer-related research. | |||||||||||||||||||||
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