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Cat. No.: HY-189951

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Pim-1 kinase-IN-18

Pim-1 kinase-IN-18 is a Pim-1 kinase inhibitor with an IC₅₀of 5.77 µM. Pim-1 kinase-IN-18 inhibits Pim serine/threonine kinase activity by occupying the ATP binding site, its pyrazole ring forms dual polar interactions with residues in the catalytic region, and its oxindole binds to the hinge region. Pim-1 kinase-IN-18 can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 260046-94-4
Formula: C₁₉H₁₅N₃O₂
Molecular Weight:317.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pim-1 kinase-IN-18 Chemical Structure

CAS No.: 260046-94-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

human PIM1

5.77 μM (IC₅₀)

All Pim Isoforms :

In Vitro

Pim-1 kinase-IN-18 (compound 6) (5.08 nM-100 µM; 1 h) inhibits human Pim-1 kinase with an IC₅₀ of 5.77 µM in a Z′-LYTE fluorescence-based biochemical assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 260046-94-4
Molecular Weight 317.34
Formula C₁₉H₁₅N₃O₂
SMILES

COC1=CC=C(C2=NNC=C2/C=C3C(C=CC=C4)=C4NC/3=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Al Zoubi R, et al. Structural Prerequisites for Pim-1 Kinase Inhibition and the Identification of a Pyrazolyl-Methylene-Indolinone Hit. Drug design, development and therapy. 2026;20:610139.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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Pim-1 kinase-IN-18

All Pim Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Pim-1 kinase-IN-18 Related Classifications

HY-189951 Related Classifications

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