2631059-94-2
2631059-94-2
Chemical Structure
IKZF1-degrader-4
- CAS No.: 2631059-94-2
- Formula:C12H11N3O3
- Molecular Weight:245.23
InChIKey: DLNLHPREQBRVET-UHFFFAOYSA-N
SMILES: CC1=CC2=C(C(N3CCC(NC3=O)=O)=NO2)C=C1
Biological Activity: IKZF1-degrader-4 is an IKZF1 molecular glue degrader with an EC50 of 6 nM. IKZF1-degrader-4 binds to the cereblon (CRBN) E3 ubiquitin ligase complex, alters its substrate recognition specificity, and potently induces ubiquitination and proteasomal degradation of IKZF1 protein. I-13 is applicable for cancer-related research[1].
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IKZF1-degrader-4 | IKZF1-degrader-4 is an IKZF1 molecular glue degrader with an EC50 of 6 nM. IKZF1-degrader-4 binds to the cereblon (CRBN) E3 ubiquitin ligase complex, alters its substrate recognition specificity, and potently induces ubiquitination and proteasomal degradation of IKZF1 protein. I-13 is applicable for cancer-related research. | |||||||||||||||||||||
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