IKZF1-degrader-4
IKZF1-degrader-4 is an IKZF1 molecular glue degrader with an EC50 of 6 nM. IKZF1-degrader-4 binds to the cereblon (CRBN) E3 ubiquitin ligase complex, alters its substrate recognition specificity, and potently induces ubiquitination and proteasomal degradation of IKZF1 protein. I-13 is applicable for cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 2631059-94-2
- Formula: C12H11N3O3
- Molecular Weight:245.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
[1]|
IKZF1 6 nM (EC50) |
In Vitro
Chemical Information
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CAS No. 2631059-94-2
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Molecular Weight 245.23
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Formula C12H11N3O3
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SMILES
CC1=CC2=C(C(N3CCC(NC3=O)=O)=NO2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)