2687960-88-7
Chemical Structure
Androsterone glucuronide-d4 sodium
Synonym(s): ADT-G-d4 sodium
- CAS No.: 2687960-88-7
- Formula:C25H33D4NaO8
- Molecular Weight:492.57
IUPAC Name: sodium (2S,3S,4S,5R,6R)-6-(((3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxohexadecahydro-1H-cyclopenta[a]phenanthren-3-yl-2,2,4,4-d4)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
InChIKey: FEOCZWNDILZJAD-FADRMDRFSA-M
SMILES: C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C([2H])([2H])[C@@H](C([2H])([2H])C2)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(O[Na])=O)([H])[C@@]5([H])[C@](CC3)(C(CC5)=O)C
Biological Activity: Androsterone glucuronide-d4 (ADT-G-d4) sodium is the deuterated-labeled Androsterone glucuronide sodium (HY-113104A). Androsterone glucuronide (ADT-G) sodium is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide sodium levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide sodium can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne[1][2][3][4][5][6][7][8].
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Androsterone glucuronide-d4 sodium | Androsterone glucuronide-d4 (ADT-G-d4) sodium is the deuterated-labeled Androsterone glucuronide sodium (HY-113104A). Androsterone glucuronide (ADT-G) sodium is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide sodium levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide sodium can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne. | |||||||||||||||||||||
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Androsterone glucuronide-d5 | Androsterone glucuronide-d5 (ADT-G-d5) is the deuterated-labeled Androsterone glucuronide (HY-113104). Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne. | |||||||||||||||||||||
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Androsterone glucuronide-d4 | 95.1% | Androsterone glucuronide-d4 (ADT-G-d4) is the deuterated-labeled Androsterone glucuronide (HY-113104). Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne. | ||||||||||||||||||||
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Androsterone glucuronide | Androsterone glucuronide (ADT-G) is a major phase II glucuronidated metabolite of androgens (such as testosterone and dihydrotestosterone) in the human body and can be found in urine. Androsterone glucuronide levels can reflect the absorption and hepatic metabolism of testosterone. Androsterone glucuronide can be used in research on hirsutism, polycystic ovary syndrome, and moderate acne. | |||||||||||||||||||||
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References
- [1]. Guillemette CH, et al. Levels of plasma C19 steroids and 5 alpha-reduced C19 steroid glucuronides in primates, rodents, and domestic animals. American Journal of Physiology-Endocrinology and Metabolism. 1996 Aug 1;271(2):E348-53.
- [2]. Bélanger A, et al. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues. The Journal of steroid biochemistry and molecular biology. 1998 Apr;65(1-6):301-10.
- [3]. Grosse L, et al. Androgen Glucuronidation in Mice: When, Where, and How. Biology. 2022 Mar 05;11(3):403.
- [4]. Qin X, et al. New insights into the androgen biotransformation in prostate cancer: A regulatory network among androgen, androgen receptors and UGTs. Pharmacological research. 2016 Apr;106:114-122.
- [5]. Kaminski RM, et al. Anticonvulsant activity of androsterone and etiocholanolone. Epilepsia. 2005 Jun;46(6):819-27. [Content Brief]
- [6]. Ponzetto F, et al. Single-run UHPLC-MS/MS method for simultaneous quantification of endogenous steroids and their phase II metabolites in serum for anti-doping purposes. Talanta. 2023 Apr 01;255:124218.
- [7]. Cho LW, et al. Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome. BMC endocrine disorders. 2017 May 19;17(1):26.
- [8]. Carmina E, et al. The association of serum androsterone glucuronide with inflammatory lesions in women with adult acne. Journal of endocrinological investigation. 2002 Oct;25(9):765-8.
