2708270-99-7
2708270-99-7
Chemical Structure
SIMR3030
- CAS No.: 2708270-99-7
- Formula:C27H29N3O2
- Molecular Weight:427.54
IUPAC Name: (7bS,9aR,16aR)-9a,12-dimethoxy-2,7,7b,8,9,9a,10,15,16,16a-decahydro-1H-indolo[3',2':8,9]quinolizino[4,3-b]carbazole
InChIKey: RGWTYAOYPDDREZ-ZWEKWIFMSA-N
SMILES: [H][C@@]12CC[C@]3(CC4=C(NC5=C4C=C(C=C5)OC)C[C@]3(N1CCC6=C2NC7=CC=CC=C76)[H])OC
Biological Activity: SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice[1].
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SIMR3030 | SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice. | |||||||||||||||||||||
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