272445-71-3
Chemical Structure
8-Br-cGMP-AM
- CAS No.: 272445-71-3
- Formula:C13H15BrN5O9P
- Molecular Weight:496.16
IUPAC Name: (((4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl acetate
InChIKey: IXDMZNRBGKDMOW-IMPUYNKFSA-N
SMILES: O[C@@H]1[C@H](OP2(OCOC(C)=O)=O)[C@@H](CO2)O[C@H]1N3C(Br)=NC4=C3N=C(N)NC4=O
Biological Activity: 8-Br-cGMP-AM is a cGMP analog. 8-Br-cGMP-AM is a membrane-permeable, bioactivatable acetoxymethyl ester designed to avoid rapid cGMP turnover. 8-Br-cGMP-AM mediates the phosphorylation of CRP4. 8-Br-cGMP-AM has anticancer activity against leukemia. 8-Br-cGMP-AM can be used for research on acute myeloid leukemia[1][2][3].
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8-Br-cGMP-AM | 8-Br-cGMP-AM is a cGMP analog. 8-Br-cGMP-AM is a membrane-permeable, bioactivatable acetoxymethyl ester designed to avoid rapid cGMP turnover. 8-Br-cGMP-AM mediates the phosphorylation of CRP4. 8-Br-cGMP-AM has anticancer activity against leukemia. 8-Br-cGMP-AM can be used for research on acute myeloid leukemia. | |||||||||||||||||||||
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References
- [1]. Gerninghaus H, et al. Nociceptor-specific signaling of the receptor guanylyl cyclase Npr2 contributes to acute and persistent pain. Science signaling. 2025 Jun 03;18(889):eadq4238.
- [2]. Butt E, et al. cGMP-dependent protein kinase modulators. Handbook of experimental pharmacology. 2009. [Content Brief]
- [3]. Schwede F, et al. Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorganic & medicinal chemistry letters. 2000 Mar 20;10(6):571-3.
