2768099-51-8
2768099-51-8
Chemical Structure
KRAS G12C degrader-1
- CAS No.: 2768099-51-8
- Formula:C63H75ClN14O6
- Molecular Weight:1159.81
InChIKey: RKQABCMDWYZJBX-OLCJBLMYSA-N
SMILES: O=C(C=C)N1CCN(C2=NC(OC[C@H]3N(C)C[C@@H](N4CCN(C(C5CCN(CC6=CC=C(N7C(C(NCC)=O)=NN=C7C8=C(O)C=C(O)C(C(C)C)=C8)C=C6)CC5)=O)CC4)C3)=NC9=C2CCN(C%10=C(C(Cl)=CC=C%11)C%11=CC=C%10)C9)C[C@@H]1CC#N
Biological Activity: KRAS G12C degrader-1 (compound 283) is a potent KRASG12C chaperone-mediated protein (CHAMP) degrader with DC50 < 100 nM. KRAS G12C degrader-1 binds to KRASG12C and HSP90, inducing ubiquitination and proteasomal degradation of KRASG12C. KRAS G12C degrader-1 can be used for research on KRASG12C-mutant cancers[1].
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KRAS G12C degrader-1 | KRAS G12C degrader-1 (compound 283) is a potent KRASG12C chaperone-mediated protein (CHAMP) degrader with DC50 < 100 nM. KRAS G12C degrader-1 binds to KRASG12C and HSP90, inducing ubiquitination and proteasomal degradation of KRASG12C. KRAS G12C degrader-1 can be used for research on KRASG12C-mutant cancers. | |||||||||||||||||||||
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