2770023-22-6
Chemical Structure
Coumarin-based kinetic stabilizer-3
- CAS No.: 2770023-22-6
- Formula:C33H34N6O4
- Molecular Weight:578.66
InChIKey: CXXFDRBIXJJLGT-HSZRJFAPSA-N
SMILES: CC(C1=CC=C(O[C@@H](C2=CC=CC=C2)C)C=C1OC3=O)=C3CCN4CC5(CCN(C6=NC=CN7C6=NC=C7)CC5)NC4=O
Biological Activity: Coumarin-based kinetic stabilizer-3 (compound (R)-83) is a full-length immunoglobulin light chain (FL LC) kinetic stabilizer and a derivative of coumarin. Coumarin-based kinetic stabilizer-3 binds to and stabilizes the amyloidogenic WIL-FL T46L/F49Y dimer (EC50 < 2.5 nM) and the native state of WIL-FL (EC50 = 4.1 nM), slows misfolding, proteolysis, and aggregation, and antagonizes amyloidogenic unfolding. Coumarin-based kinetic stabilizer-3 can be used in research on immunoglobulin light chain (AL) amyloidosis[1].
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Coumarin-based kinetic stabilizer-3 | Coumarin-based kinetic stabilizer-3 (compound (R)-83) is a full-length immunoglobulin light chain (FL LC) kinetic stabilizer and a derivative of coumarin. Coumarin-based kinetic stabilizer-3 binds to and stabilizes the amyloidogenic WIL-FL T46L/F49Y dimer (EC50 < 2.5 nM) and the native state of WIL-FL (EC50 = 4.1 nM), slows misfolding, proteolysis, and aggregation, and antagonizes amyloidogenic unfolding. Coumarin-based kinetic stabilizer-3 can be used in research on immunoglobulin light chain (AL) amyloidosis. | |||||||||||||||||||||
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