Coumarin-based kinetic stabilizer-3
Coumarin-based kinetic stabilizer-3 (compound (R)-83) is a full-length immunoglobulin light chain (FL LC) kinetic stabilizer and a derivative of coumarin. Coumarin-based kinetic stabilizer-3 binds to and stabilizes the amyloidogenic WIL-FL T46L/F49Y dimer (EC50 < 2.5 nM) and the native state of WIL-FL (EC50 = 4.1 nM), slows misfolding, proteolysis, and aggregation, and antagonizes amyloidogenic unfolding. Coumarin-based kinetic stabilizer-3 can be used in research on immunoglobulin light chain (AL) amyloidosis.
For research use only. We do not sell to patients.
- CAS No.: 2770023-22-6
- Formula: C33H34N6O4
- Molecular Weight:578.66
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Coumarin-based kinetic stabilizer-3 (10 μM; 1 h) kinetically stabilizes the WIL-FL T46L/F49Y/C214S light chain dimer, conferring a 0.63-fold protection against Proteinase K hydrolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2770023-22-6
-
Molecular Weight 578.66
-
Formula C33H34N6O4
-
SMILES
CC(C1=CC=C(O[C@@H](C2=CC=CC=C2)C)C=C1OC3=O)=C3CCN4CC5(CCN(C6=NC=CN7C6=NC=C7)CC5)NC4=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Coumarin-based kinetic stabilizer-3 Related Classifications
HY-186372 Related Classifications
Powered by Bioz