287184-75-2
Chemical Structure
GPQ-W
- CAS No.: 287184-75-2
- Formula:C68H105N25O23S2
- Molecular Weight:1704.85
InChIKey: BNLLSXVQMLIVTN-BTPMJUFXSA-N
SMILES: O=C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(NCC(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: GPQ-W is a synthetic peptide containing a type I collagen-derived protease cleavage site and serves as a protease-degradable crosslinker in PEG-4MAL/RGD synthetic hydrogels. GPQ-W is cleaved by cell-secreted matrix metalloproteinases, enabling cell-mediated matrix degradation and remodeling. GPQ-W, as a PEG-4MAL hydrogel component, supports the in vitro generation of human intestinal and lung organoids from hPSC-derived spheroids, long-term survival of intestinal organoids, normal epithelial cyst polarity, and lumen formation at the rapidly degrading crosslinker threshold level. GPQ-W can be used in research related to intestinal mucosal injury and organoid transplantation[1][2].
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GPQ-W | GPQ-W is a synthetic peptide containing a type I collagen-derived protease cleavage site and serves as a protease-degradable crosslinker in PEG-4MAL/RGD synthetic hydrogels. GPQ-W is cleaved by cell-secreted matrix metalloproteinases, enabling cell-mediated matrix degradation and remodeling. GPQ-W, as a PEG-4MAL hydrogel component, supports the in vitro generation of human intestinal and lung organoids from hPSC-derived spheroids, long-term survival of intestinal organoids, normal epithelial cyst polarity, and lumen formation at the rapidly degrading crosslinker threshold level. GPQ-W can be used in research related to intestinal mucosal injury and organoid transplantation. | |||||||||||||||||||||
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References
- [1]. Cruz-Acuña R, et al. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc. 2018 Sep;13(9):2102-2119. doi: 10.1038/s41596-018-0036-3. Erratum in: Nat Protoc. 2019 Jul;14(7):2258. [Content Brief]
- [2]. Braham MVJ, et al. Enhanced Human Antigen-Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells. Advanced healthcare materials. 2026 Jun;15(22):e04886.
