GPQ-W
GPQ-W is a synthetic peptide containing a type I collagen-derived protease cleavage site and serves as a protease-degradable crosslinker in PEG-4MAL/RGD synthetic hydrogels. GPQ-W is cleaved by cell-secreted matrix metalloproteinases, enabling cell-mediated matrix degradation and remodeling. GPQ-W, as a PEG-4MAL hydrogel component, supports the in vitro generation of human intestinal and lung organoids from hPSC-derived spheroids, long-term survival of intestinal organoids, normal epithelial cyst polarity, and lumen formation at the rapidly degrading crosslinker threshold level. GPQ-W can be used in research related to intestinal mucosal injury and organoid transplantation.
For research use only. We do not sell to patients.
- CAS No.: 287184-75-2
- Formula: C68H105N25O23S2
- Molecular Weight:1704.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
GPQ-W-crosslinked PEG-4MAL hydrogels support the in vitro generation of HIOs from hPSC-derived intestinal spheroids, form lumens within 4-5 d, and can maintain HIOs for up to approximately 21 d with passaging for three generations[1].
GPQ-W cross-linked 3D FRC cultures enhance human tonsillar B/T cell survival and antigen-specific B cell responses, and promote GC/ASC differentiation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 287184-75-2
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Molecular Weight 1704.85
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Formula C68H105N25O23S2
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SMILES
O=C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(NCC(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
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Sequence
Gly-Cys-Arg-Asp-Gly-Pro-Gln-Gly-Ile-Trp-Gly-Gln-Asp-Arg-Cys-Gly
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Sequence Shortening
GCRDGPQGIWGQDRCG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPQ-W Related Classifications
HY-P12384 Related Classifications
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Keywords
- GPQ-W
- 287184-75-2
- Biochemical Assay Reagents
- PEG-4MAL hydrogels
- cell-mediated matrix degradation
- collagen-derived peptide cross-linker
- colonic wound repair
- epithelial cyst polarity
- human intestinal organoids
- human lung organoids
- lymphoid cultures
- protease-degradable
- three-dimensional cell culture
- Inhibitor
- inhibitor
- inhibit