2891801-74-2
Chemical Structure
HDAC6-IN-88
- CAS No.: 2891801-74-2
- Formula:C23H25ClN2O5
- Molecular Weight:444.91
InChIKey: CCZWPCUZIDKTNX-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(NCCCCCCC(OC)=O)=O)C2=C1C(C3=CC=CC(OC)=C3N2)=O
Biological Activity: HDAC6-IN-88 is a selective HDAC6 inhibitor with an IC50 of 28 nM. HDAC6-IN-88 directly binds to HDAC6 and prevents the deacetylation of α-tubulin (α-tubulin) and Hsp90. HDAC6-IN-88 enhances microglial phagocytosis, promotes microtubule stabilization, and inhibits NF-κB pathway activation. DAC6-IN-88 ameliorates cognitive deficits in Aβ1-42 oligomer-induced mice, reverses HDAC6-related changes in hippocampal biomarkers, and exhibits good biosafety. HDAC6-IN-88 can be used for research related to Alzheimer's disease[1].
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HDAC6-IN-88 | HDAC6-IN-88 is a selective HDAC6 inhibitor with an IC50 of 28 nM. HDAC6-IN-88 directly binds to HDAC6 and prevents the deacetylation of α-tubulin (α-tubulin) and Hsp90. HDAC6-IN-88 enhances microglial phagocytosis, promotes microtubule stabilization, and inhibits NF-κB pathway activation. DAC6-IN-88 ameliorates cognitive deficits in Aβ1-42 oligomer-induced mice, reverses HDAC6-related changes in hippocampal biomarkers, and exhibits good biosafety. HDAC6-IN-88 can be used for research related to Alzheimer's disease. | |||||||||||||||||||||
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