2892235-56-0
Chemical Structure
photoCORM-1
- CAS No.: 2892235-56-0
- Formula:C33H32Cl2N2O6
- Molecular Weight:623.52
IUPAC Name: 4,4'-(9-ethyl-9H-carbazole-3,6-diyl)bis(1,3-dioxol-2-one)
InChIKey: UREMSFRGCFFTAX-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(N(C3=CC=C(C=C32)C(O4)=COC4=O)CC)C=C1)COC(CCCC5=CC=C(C=C5)N(CCCl)CCCl)=O
Biological Activity: photoCORM-1 is a visible light-induced carbon monoxide-releasing molecule and antibacterial (Antibacterial) agent. photoCORM-1 produces non-toxic byproducts and turns on fluorescence through pbt decoordination under blue, green, or red light. photoCORM-1 is internalized by cancer cells and normal cells, localizing to the cytoplasm and mitochondria. photoCORM-1 induces apoptosis (Apoptosis) under light irradiation. photoCORM-1 exhibits anticancer activity against lung cancer under light irradiation. photoCORM-1 exhibits antibacterial and antibiofilm activity against ESKAPE bacteria. photoCORM-1 can be used for research on breast cancer and LPS-induced inflammation[1][2][3][4].
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photoCORM-1 | photoCORM-1 is a visible light-induced carbon monoxide-releasing molecule and antibacterial (Antibacterial) agent. photoCORM-1 produces non-toxic byproducts and turns on fluorescence through pbt decoordination under blue, green, or red light. photoCORM-1 is internalized by cancer cells and normal cells, localizing to the cytoplasm and mitochondria. photoCORM-1 induces apoptosis (Apoptosis) under light irradiation. photoCORM-1 exhibits anticancer activity against lung cancer under light irradiation. photoCORM-1 exhibits antibacterial and antibiofilm activity against ESKAPE bacteria. photoCORM-1 can be used for research on breast cancer and LPS-induced inflammation. | |||||||||||||||||||||
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References
- [1]. Popova M, et al. Visible-Light-Activated Quinolone Carbon-Monoxide-Releasing Molecule: Prodrug and Albumin-Assisted Delivery Enables Anticancer and Potent Anti-Inflammatory Effects. Journal of the American Chemical Society. 2018 Aug 01;140(30):9721-9729.
- [2]. Wu X, et al. Synthesis, structural characterization and biological activity of quinolone-based photo-induced CO release molecules as anticancer agents. Journal of Molecular Structure. 2025 Apr 25;1328:141316.
- [3]. Singh PK, et al. BODIPY-Based Mitochondrial Targeted NIR-Responsive CO-Releasing Platform for the On-Demand Release of CO to Treat Cancer. ACS applied bio materials. 2023 Sep 18;6(9):3778-3789.
- [4]. Toscani A, et al. Development of photoactivable phenanthroline-based manganese(I) CO-Releasing molecules (PhotoCORMs) active against ESKAPE bacteria and bacterial biofilms. European journal of medicinal chemistry. 2021 Mar 05;213:113172.
