2923335-61-7
2923335-61-7
Chemical Structure
RBM39 Degrader-4
- CAS No.: 2923335-61-7
- Formula:C13H15ClN2O2S
- Molecular Weight:298.79
InChIKey: AALAHPOELVYECA-UHFFFAOYSA-N
SMILES: CCCC1CC2=C(NS1(=O)=O)C3=C(C(Cl)=CN3)C=C2
Biological Activity:
RBM39 Degrader-4 is a molecular glue degrader. RBM39 Degrader-4 binds to the DCAF15 substrate receptor of the CRL4 E3 ligase complex and promotes the formation of the DCAF15-RBM39 ternary complex (EC50 = 16.4 nM), thereby degrading the splicing factor RBM39 via the proteasome. RBM39 Degrader-4 can be used for research on colorectal cancer[1].
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RBM39 Degrader-4 | RBM39 Degrader-4 is a molecular glue degrader. RBM39 Degrader-4 binds to the DCAF15 substrate receptor of the CRL4 E3 ligase complex and promotes the formation of the DCAF15-RBM39 ternary complex (EC50 = 16.4 nM), thereby degrading the splicing factor RBM39 via the proteasome. RBM39 Degrader-4 can be used for research on colorectal cancer. |
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