2924754-26-5
2924754-26-5
Chemical Structure
CRBN modulator-3
- CAS No.: 2924754-26-5
- Formula:C22H18F3N3O4
- Molecular Weight:445.39
InChIKey: NDKDDRAVMNNUPV-UHFFFAOYSA-N
SMILES: O=C(N1)CCC(N2CC3=C(CNC(C4=CC=C(C(F)(F)F)C=C4)=O)C=CC=C3C2=O)C1=O
Biological Activity: CRBN modulator-3 is a molecular glue that binds cereblon (CRBN) in the CRL4 E3 ligase complex (binding CRBN with an IC50 = 1-10 μM). CRBN modulator-3 can be used in research on hematological malignancies such as multiple myeloma and acute myeloid leukemia[1].
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CRBN modulator-3 | CRBN modulator-3 is a molecular glue that binds cereblon (CRBN) in the CRL4 E3 ligase complex (binding CRBN with an IC50 = 1-10 μM). CRBN modulator-3 can be used in research on hematological malignancies such as multiple myeloma and acute myeloid leukemia. | |||||||||||||||||||||
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