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Cat. No.: HY-190202

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CRBN modulator-3

CRBN modulator-3 is a molecular glue that binds cereblon (CRBN) in the CRL4 E3 ligase complex (binding CRBN with an IC₅₀ = 1-10 μM). CRBN modulator-3 can be used in research on hematological malignancies such as multiple myeloma and acute myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 2924754-26-5
Formula: C₂₂H₁₈F₃N₃O₄
Molecular Weight:445.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRBN modulator-3 Chemical Structure

CAS No.: 2924754-26-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

CEREBLON

All Ligands for E3 Ligase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	EC50	< 1 μM	Treatment for 72 h inhibits the proliferation of MOLM-13 cells. Treatment for 72 h inhibits the proliferation of MOLM-13 cells.	en?oq=WO2023081224+A1

In Vitro

Anti-cancerOthers

Anti-cancer

CRBN modulator-3 (compound 13) (72 h) has an EC₅₀ < 1 μM against MOLM-13 cell proliferation^[1].

Others

CRBN modulator-3 binds CRBN with an IC₅₀ of 1-10 μM (Grade B) in a competitive fluorescence polarization assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2924754-26-5
Molecular Weight 445.39
Formula C₂₂H₁₈F₃N₃O₄
SMILES

O=C(N1)CCC(N2CC3=C(CNC(C4=CC=C(C(F)(F)F)C=C4)=O)C=CC=C3C2=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nishiguchi G A, et al. Substituted n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)benzamide analogs as modulators of cereblon protein. WO2023081224A1. WIPO. 2023‑05‑11.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CRBN modulator-3

All Ligands for E3 Ligase Isoforms