2946669-64-1
2946669-64-1
Chemical Structure
GSPT1 degrader-22
- CAS No.: 2946669-64-1
- Formula:C32H33N5O5
- Molecular Weight:567.63
InChIKey: LICDRSSYURATJU-UHFFFAOYSA-N
SMILES: O=C(N1)CCC(N2CC3=C(C=CC(NC(CC4CCN(C(NCC5=CC=CC6=CC=CC=C65)=O)CC4)=O)=C3)C2=O)C1=O
Biological Activity: GSPT1 degrader-22 is a cereblon (CRBN)-recruiting molecular glue degrader containing a glutarimide scaffold, which promotes the ubiquitination and proteasomal degradation of GSPT1 via the CUL4CRBN E3 ligase. GSPT1 degrader-22 can be used for research on hematologic malignancies and solid tumors[1].
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GSPT1 degrader-22 | GSPT1 degrader-22 is a cereblon (CRBN)-recruiting molecular glue degrader containing a glutarimide scaffold, which promotes the ubiquitination and proteasomal degradation of GSPT1 via the CUL4CRBN E3 ligase. GSPT1 degrader-22 can be used for research on hematologic malignancies and solid tumors. | |||||||||||||||||||||
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