2952554-69-5
Chemical Structure
MK-7845
- CAS No.: 2952554-69-5
- Formula:C24H38F2N4O6
- Molecular Weight:516.58
InChIKey: DAVWSCGJIBGBHZ-IQWQSGHPSA-N
SMILES: CNC(C([C@@H](NC([C@@H]1[C@H]2CCC[C@H]2CN1C([C@H](C(C)(C)C)NC(OC)=O)=O)=O)CCC(F)(F)C)=O)=O
Biological Activity: MK-7845 is an orally active and selective SARS-CoV-2 3CL protease (Mpro) inhibitor with an IC50 of 8.7 nM. MK-7845 forms a reversible covalent adduct with the catalytic cysteine, interacting with histidine through its difluorobutyl P1 group. MK-7845 exhibits antiviral activity against the WA1/2020 wild-type, Delta, and Omicron strains. MK-7845 demonstrates in vivo efficacy in a mouse SARS-CoV-2 infection model, reducing lung viral load and preventing body weight loss. MK-7845 can be used for research related to SARS-CoV-2 viral infection[1].
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MK-7845 | MK-7845 is an orally active and selective SARS-CoV-2 3CL protease (Mpro) inhibitor with an IC50 of 8.7 nM. MK-7845 forms a reversible covalent adduct with the catalytic cysteine, interacting with histidine through its difluorobutyl P1 group. MK-7845 exhibits antiviral activity against the WA1/2020 wild-type, Delta, and Omicron strains. MK-7845 demonstrates in vivo efficacy in a mouse SARS-CoV-2 infection model, reducing lung viral load and preventing body weight loss. MK-7845 can be used for research related to SARS-CoV-2 viral infection. | |||||||||||||||||||||
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