2988110-08-1
2988110-08-1
Chemical Structure
IKZF2 degrader-11
- CAS No.: 2988110-08-1
- Formula:C23H30FN3O4
- Molecular Weight:431.50
InChIKey: KYNPZQPZHCVFFK-YYWNBFMDSA-N
SMILES: CCC(N[C@H]1CCCO[C@@H]1CC2=C(F)C3=C(C(N(C4CCC(NC4=O)=O)C3)=O)C=C2)C
Biological Activity: IKZF2 degrader-11 is an isoindolinone-based CRBN molecular glue degrader containing a tetrahydropyran substituent that recruits CRL4CRBN to ubiquitinate and efficiently degrade IKZF2 (EC50 = 3 nM, Dmax = 97%). IKZF2 degrader-11 can be used in cancer research[1].
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IKZF2 degrader-11 | IKZF2 degrader-11 is an isoindolinone-based CRBN molecular glue degrader containing a tetrahydropyran substituent that recruits CRL4CRBN to ubiquitinate and efficiently degrade IKZF2 (EC50 = 3 nM, Dmax = 97%). IKZF2 degrader-11 can be used in cancer research. | |||||||||||||||||||||
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